Endocrine Abstracts

Introduction: We present a challenging case of central diabetes insipidus secondary to hypothalamic large B cell lymphoma. These are rare tumors accounting for less than 1% of lymphomas. Conventional treatment involves the MATRIX regime (methotrexate, rituximab, thiotepa, cytarabine) chemotherapy, coupled with intensive intravenous fluid therapy to avoid methotrexate toxicity. The main challenges in the management of this case were maintaining fluid and electrolyte balance in ...